Russian Black Terrier RBT Club Page 7.

RBTclub Health Topics

Health Topics Kennel Club. Dog Health Test Search http://www.the-kennel-club.org.uk/services/public/health/search/Default.aspx Health Matters, the Club will be covering all relevant issues for the breed. Any health problems you have found and which can be recorded for the breed please contact the Club Health coordinators Lead Health Co-ordinator Kathy Gallagher kathy@machenka.fsnet.co.uk Janet Huxley janet@robroyd.co.uk Steve Thomson steve_snt@hotmail.co.uk MEDICAL: Please Note: Articles pertaining to health related topics are for information only. Readers should seek the advice of a relevant practitioner before attempting to diagnose or administer any medication. Mention of any product or procedure should not be seen as an endorsement for said product or procedure.

LATEST NEWS Urate Stones-Uric Acid Excretion 18th Feb 2009 DNA testing is now available in the UK for Urate Stones-Uric Acid Excretion (Hyperuricosuria). details at; http://www.aht.org.uk/ A.H.T. Animal Health Trust. All that is required to have your dog tested is to take a cheek swab sample from your dogs mouth. We urge all RBT owners to apply for the swab and then we can move one step further to eradicate this health problem out of the breed which can be only be achieved by sensible breeding programmes.The club is here for the RBT’s health and its well being. The breed is relatively small in numbers here in the UK so please test your dog When you have had your RBT tested would you please send your results to the RBT Club Lead Health Co-ordinator Kathy Gallagher kathy@machenka.fsnet.co.uk or Hon Sec Janet Huxley Janet@robroyd.co.uk

LATEST NEWS 10/11/2008 Urate Urolithiasis Paper Published and Genetic Test will be offered by Dec. 1 I am happy to say that the paper about the urate urolithiasis mutation is out!!! This paper is the initial study identifying the mutation. The paper can be viewed, for free, on PLoS genetics: http://www.plosgenetics.org/article/info%3Ad oi%2F10.1371%2Fjournal.pgen.1000246 ***This does not include the allele frequencies of the mutation in Black Russian Terriers and Bulldogs (that will be the next publication). Please feel free to let your breed clubs know about it. The genetic test should be offered through the UC Davis Veterinary Genetics Lab by Dec. 1. Please refer to their website for updates: http://www.vgl.ucdavis.edu/services/index.php The article has been in the news, I thought I’d share with you: Official UC Davis Press Release: http://www.news.ucdavis.edu/search/news_det ail.lasso?id=8853 Gene Mutation in Dalmatians Sheds Light on Kidney Stones in Humans Finding explained high levels of uric acid in dog breed US News & World Report, (HealthDay News) http://health.usnews.com/articles/health/health day/2008/11/07/gene-mutation-in-dalmatians- sheds-light-on-kidney.html Gene Responsible for Bladder Stones in Dalmatians Found Veterinary Practice News (online) http://www.veterinarypracticenews.com/vet- breaking-news/2008/11/07/gene-responsible- for-bladder-stones-in-dalmatians-found.aspx I will notify you once the allele frequency paper is published, Thank you all for all the help, Nili Nili Karmi Vet Student, Class of 2010 Genetics Ph.D. candidate Dept. of Population Health and Reproduction School of Veterinary Medicine, University of CA in Davis, Davis, CA 95616 Tel. (530) 754- 7289

LATEST NEWS 10/11/2008 Dear Bulldog and Black Russian Terrier enthusiasts, We are pleased to announce that a DNA test for canine hyperuricosuria (huu), the production of high levels of urate in the urine that can result in bladder stones, is now available through the Veterinary Genetics Laboratory at the University of California, Davis. The test is $65 per dog and a cheek swab sample is required. Results are available within five to ten business days. Information regarding sample submission can be found online at http://www.vgl.ucdavis.edu/services/dog.php. The Veterinary Genetics Laboratory is a non- profit service laboratory. All proceeds from the huu test will be directly applied to further research on canine inherited diseases. The available DNA test is based on research that was conducted in our laboratory at the University of California, Davis, School of Veterinary Medicine. A scientific manuscript detailing the identification of the mutation was published November 7, 2008 in the journal Public Library of Science (PLos) Genetics. These results are publicly available at http://www.plosgenetics.org/home.action . The graduate student in the laboratory that has been evaluating the mutation in Bulldogs and Black Russian Terriers, Nili Karmi, is continuing her work in this area. The allele frequency of the mutation in affected breeds will be reported in the near future. Knowing the allele frequency of the mutation in Bulldogs and Black Russian Terriers will better enable breeders to make educated breeding decisions with respect to this condition.